|
KMID : 0371320100780050283
|
|
Journal of the Korean Surgical Society
2010 Volume.78 No. 5 p.283 ~ p.289
|
|
|
Association of RNase3 Polymorphisms with the Susceptibility of Gastric Cancer
|
|
Koo Ja-Wook
Kang Dong-Baek
Park Won-Cheol
Lee Young-Hwan
Kang In-Hong
Chae Soo-Cheon
Lee Jeong-Kyun
|
|
|
Abstract
|
|
|
Purpose: RNase3 is a secretory ribonuclease, which is found in the eosinophilic leukocyte and involved in the innate immune system. Its cytotoxic activity is effective against a wide range of pathogens. We performed a case-control study to examine the relationship between RNase3 polymorphisms and the susceptibility of gastric cancer in Korean people.
Methods: Blood sampling of stomach cancer and healthy persons groups were performed, Taqman in g.-550A＞G, polymerase chain reaction-restriction fragment length polymorphism in g.371C＞G, and high-resolution melt in g.499C＞G were analyzed. The three single nucleotide polymorphisms g.-550A＞G, g.371C＞G, and g.499C＞G in RNase3 and their haplotypes were analyzed.
Results: The genotype and allele frequencies of RNase3 g.-550A＞G and g.371C＞G were not significantly increased in susceptibility of gastric cancer than control group. But, RNase3 CC genotype was associated with a significantly increased susceptibility of gastric cancer than control group (P=0.002). Also, RNase3 CC genotype was more specifically associated with a significantly increased susceptibility of middle and lower gastric cancer than upper gastric cancer (P=0.002). In haplotype of RNase3 SNP g.-550A, g.371G, and g.499C, there was significantly susceptibility of gastric cancer (P=0.004), and more specific influence on middle and lower gastric cancer than upper gastric cancer (P=0.006 vs 0.054).
Conclusion: RNase3 g.499C＞G polymorphism may influence gastric cancers, and have a more specific influence on middle and lower gastric cancer rather than upper gastric cancer. But RNase3 g.-550A＞G, g.371C＞G polymorphisms need careful interpretation and confirmation in more larger studies.
|
|
|
KEYWORD
|
|
|
RNase3, Polymorphism, Gastric cancer
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|